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VUF10166

CAT: 0804-HY-100552-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-100552-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
VUF10166 is a potent and high-affinity 5-HT3 receptor antagonist, with Ki values of 0.04 nM (5-HT3A) and 22 nM (5-HT3AB) . VUF10166 inhibits 5-HT-induced responses at 5-HT3A and 5-HT3AB receptors at nanomolar concentrations. At 5-HT3 receptor, VUF10166 at higher concentrations also acts as a partial agonist, with an EC50 of 5.2 μM[1].
CAS Number
155584-74-0
UNSPSC
12352005
Hazard Statement
H301, H311, H331
Target
5-HT Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/vuf10166.html
Concentration
10mM
Purity
99.83
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CN1CCN(C2=NC3=CC=CC=C3N=C2Cl)CC1
Molecular Formula
C13H15ClN4
Molecular Weight
262.74
Precautions
H301, H311, H331
References & Citations
[1]Thompson AJ, et al. VUF10166, a novel compound with differing activities at 5-HT₃A and 5-HT₃AB receptors. J Pharmacol Exp Ther. 2012 May;341 (2) :350-9.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
5-HT3 Receptor; lactoferrin

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