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BAY 2965501

CAT: 0957-E1692-02Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0957-E1692-02Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BAY 2965501 is a potent selective inhibitor of diacylglycerol kinases zeta (DGKζ), restores T-cell cellular DAG level, and induces pERK activation in anergic T-cells via DGK inhibition to assist T-cell mediate tumor cell kill.
CAS Number
2732902-08-6
Target
Others
Activity
Others
Molecular Formula
C20H19FN4O3S

Chemical Information

Veludacigib

Veludacigib is an orally bioavailable inhibitor of diacylglycerol kinase zeta (DGKzeta), with potential antineoplastic activity. Upon oral administration, veludacigib inhibits the activity of DGKzeta. This prevents the phosphorylation of diacylglycerol (DAG) to phosphatidic acid (PA), and modulates the DAGzeta-regulated cellular signaling pathways. This may inhibit the proliferation of tumor cells in which DGKzeta is overactivated. DGKzeta is overexpressed in certain cancer cells and plays an important role in tumor cell survival. DAGzeta may also play a key role in tumor immunosuppression.

CAS Number2732902-08-6
PubChem CID166792554
IUPAC Name(2R)-2-(N-[4-amino-5-(4-methoxybenzoyl)-1,3-thiazol-2-yl]-4-fluoroanilino)propanamide
Molecular FormulaC20H19FN4O3S
Molecular Weight414.5
XLogP4.3
Topological Polar Surface Area140
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count8
Rotatable Bond Count7
Heavy Atom Count29
Formal Charge0
Complexity582
SMILES
C[C@H](C(=O)N)N(C1=CC=C(C=C1)F)C2=NC(=C(S2)C(=O)C3=CC=C(C=C3)OC)N
InChI
InChI=1S/C20H19FN4O3S/c1-11(19(23)27)25(14-7-5-13(21)6-8-14)20-24-18(22)17(29-20)16(26)12-3-9-15(28-2)10-4-12/h3-11H,22H2,1-2H3,(H2,23,27)/t11-/m1/s1
InChIKey
HSBUVKDEUUJREZ-LLVKDONJSA-N
Chemical Structure
2D Structure
2D structure of Veludacigib
CAS: 2732902-08-6
CID: 166792554
Formula: C20H19FN4O3S
MW: 414.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight414.5
XLogP34.3
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count8
Rotatable Bond Count7
Exact Mass414.11618982
Monoisotopic Mass414.11618982
Topological Polar Surface Area140 Ų
Heavy Atom Count29
Formal Charge0
Complexity582
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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CatalogName
MBS5815272BAY 2965501

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