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MS4078

CAT: 0957-S0072-02Size: 10 mm/ 1 mLDry Ice: NoHazardous: No
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CAT#:0957-S0072-02Size:10 mm/ 1 mL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
MS4078 is an inhibitor and PROTAC (degrader) of ALK. MS4078 reduces the NPM-ALK protein levels in SU-DHL-1 cells and the EML4-ALK protein levels in NCI-H2228 cells with DC50 of 11 nM and 59 nM, respectively. MS4078 induces ALK protein degradation via cereblon and proteasome dependent mechanism and potently inhibits proliferation of SU-DHL-1 cells with IC50 of 33 nM.
CAS Number
2229036-62-6
Target
ALK
Activity
Protein Tyrosine Kinase
Molecular Formula
C45H52ClN9O8S
Storage Conditions
3 years -20°C powder

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