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HRX215

CAT: 0957-E1938-02Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0957-E1938-02Size:25 mg
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Description
HRX215 (Darizmetinib) is a first-in-class, highly potent, selective, and orally active inhibitor of MKK4 with an IC50 of 0.02 μM. It enhances liver regeneration, prevents liver failure following extensive hepatectomy in pigs, and has potential to prevent liver failure after major oncological liver resections or transplantation of small liver grafts in humans.
CAS Number
2369583-33-3
Synonyms
Darizmetinib
Target
P38 MAPK
Activity
MAPK
Molecular Formula
C21H17F2N5O3S

Chemical Information

Darizmetinib

Darizmetinib is a small molecule drug. The usage of the INN stem '-tinib' in the name indicates that Darizmetinib is a tyrosine kinase inhibitor. Darizmetinib has a monoisotopic molecular weight of 457.1 Da.

CAS Number2369583-33-3
PubChem CID139369660
IUPAC NameN-[2,6-difluoro-3-(5-pyridin-4-yl-2H-pyrazolo[3,4-b]pyridine-3-carbonyl)phenyl]propane-1-sulfonamide
Molecular FormulaC21H17F2N5O3S
Molecular Weight457.5
XLogP3.1
Topological Polar Surface Area126
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count9
Rotatable Bond Count7
Heavy Atom Count32
Formal Charge0
Complexity761
SMILES
CCCS(=O)(=O)NC1=C(C=CC(=C1F)C(=O)C2=C3C=C(C=NC3=NN2)C4=CC=NC=C4)F
InChI
InChI=1S/C21H17F2N5O3S/c1-2-9-32(30,31)28-19-16(22)4-3-14(17(19)23)20(29)18-15-10-13(11-25-21(15)27-26-18)12-5-7-24-8-6-12/h3-8,10-11,28H,2,9H2,1H3,(H,25,26,27)
InChIKey
WBNMARNYIFMNEP-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Darizmetinib
CAS: 2369583-33-3
CID: 139369660
Formula: C21H17F2N5O3S
MW: 457.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight457.5
XLogP33.1
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count9
Rotatable Bond Count7
Exact Mass457.10201692
Monoisotopic Mass457.10201692
Topological Polar Surface Area126 Ų
Heavy Atom Count32
Formal Charge0
Complexity761
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
C01965-25mgHRX215

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