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Pinealon

CAT: 0804-HY-P4052-02Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-P4052-02Size:50 mg
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Description
Pinealon is a 3-amino acid peptide and shows neuroprotective properties. Pinealon prevents reactive oxygen species (ROS) accumulation and suppresses the activation of ERK 1/2. Pinealon stimulates the functional activity of the main cellular elements of brain tissue, reduces the level of spontaneous cell death. Pinealon protects the rat offspring from prenatal hyperhomocysteinemia[1][2][3].
CAS Number
175175-23-2
UNSPSC
12352209
Target
ROS Kinase
Type
Peptides
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/pinealon.html
Purity
99.51
Solubility
H2O : ≥ 100 mg/mL
Smiles
O=C(N[C@@H](CC(O)=O)C(N[C@@H](CCCNC(N)=N)C(O)=O)=O)[C@H](CCC(O)=O)N
Molecular Formula
C15H26N6O8
Molecular Weight
418.40
References & Citations
[1]Khavinson V, et al. Pinealon increases cell viability by suppression of free radical levels and activating proliferative processes. Rejuvenation Res. 2011 Oct;14 (5) :535-41.|[2]G. V. Karantysh, et al. Effect of Pinealon on Learning and Expression of NMDA Receptor Subunit Genes in the Hippocampus of Rats with Experimental Diabetes. Neurochemical Journal, 2020, 14, 314-320.|[3]Arutjunyan A, et al. Pinealon protects the rat offspring from prenatal hyperhomocysteinemia. Int J Clin Exp Med. 2012;5 (2) :179-85.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)
Scientific Category
Peptides
Clinical Information
No Development Reported

Chemical Information

Glu-Asp-Arg

Glu-Asp-Arg is a tripeptide composed of L-glutamic acid, L-aspartic acid, and L-arginine joined in sequence by peptide linkages. It has a role as a neuroprotective agent. It is functionally related to a L-glutamic acid, a L-arginine and a L-aspartic acid.

CAS Number175175-23-2
PubChem CID10273502
IUPAC Name(4S)-4-amino-5-[[(2S)-3-carboxy-1-[[(1S)-1-carboxy-4-(diaminomethylideneamino)butyl]amino]-1-oxopropan-2-yl]amino]-5-oxopentanoic acid
Molecular FormulaC15H26N6O8
Molecular Weight418.40
XLogP-6.1
Topological Polar Surface Area261
Hydrogen Bond Donor Count8
Hydrogen Bond Acceptor Count10
Rotatable Bond Count14
Heavy Atom Count29
Formal Charge0
Complexity649
SMILES
C(C[C@@H](C(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)N)CN=C(N)N
InChI
InChI=1S/C15H26N6O8/c16-7(3-4-10(22)23)12(26)21-9(6-11(24)25)13(27)20-8(14(28)29)2-1-5-19-15(17)18/h7-9H,1-6,16H2,(H,20,27)(H,21,26)(H,22,23)(H,24,25)(H,28,29)(H4,17,18,19)/t7-,8-,9-/m0/s1
InChIKey
QPRZKNOOOBWXSU-CIUDSAMLSA-N
Chemical Structure
2D Structure
2D structure of Glu-Asp-Arg
CAS: 175175-23-2
CID: 10273502
Formula: C15H26N6O8
MW: 418.40
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight418.40
XLogP3-6.1
Hydrogen Bond Donor Count8
Hydrogen Bond Acceptor Count10
Rotatable Bond Count14
Exact Mass418.18121181
Monoisotopic Mass418.18121181
Topological Polar Surface Area261 Ų
Heavy Atom Count29
Formal Charge0
Complexity649
Isotope Atom Count0
Defined Atom Stereocenter Count3
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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