Products for Research Use Only
RegisterLogin

Latency-associated peptide Polyclonal Antibody

CAT: 0498-bs-4908R-TRSize: 20 µLDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0498-bs-4908R-TRSize:20 µL
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Background
Latency-associated peptide: Required to maintain the Transforming growth factor beta-1 (TGF-beta-1) chain in a latent state during storage in extracellular matrix. Associates non-covalently with TGF-beta-1 and regulates its activation via interaction with 'milieu molecules', such as LTBP1, LRRC32/GARP and LRRC33/NRROS, that control activation of TGF-beta-1. Interaction with LRRC33/NRROS regulates activation of TGF-beta-1 in macrophages and microglia (Probable) . Interaction with LRRC32/GARP controls activation of TGF-beta-1 on the surface of activated regulatory T-cells (Tregs) . Interaction with integrins (ITGAV:ITGB6 or ITGAV:ITGB8) results in distortion of the Latency-associated peptide chain and subsequent release of the active TGF-beta-1.
Synonyms
Transforming growth factor beta-1 proprotein; CED; LAP; DPD1; TGFB; TGFbeta; TGF-beta-1; TGFB1
Gene ID
7040
Swiss Prot
P01137
Cellular Locus
Secreted, Extracellular matrix
Host
Rabbit
Cross Reactivity
Human
Immunogen
101-200/390
Target
TGFB1
Clonality
Polyclonal
Conjugation
Unconjugated
Source
KLH conjugated synthetic peptide derived from human TGF beta 1/LAP
Applications
WB, ELISA, IHC-P, IHC-F, IF (IHC-P), IF (IHC-F), IF (ICC)
Purification
Purified by Protein A.
Concentration
1ug/ul
Dilution
WB (1:300-5000), ELISA (1:500-1000), IHC-P (1:200-400), IHC-F (1:100-500), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)
Buffer
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Shipped at 4C. Store at -20C for one year. Avoid repeated freeze/thaw cycles.
Specificity
The antibody targets the Latency-associated peptide (LAP), which is a cleavage product of the Transforming growth factor beta-1 proprotein (TGFB1)
Gene ID URL
7040
Isotype
IgG

Related Products

CatalogName
bs-11178RSignal Peptide Peptidase Polyclonal Antibody
bs-0274RC Peptide Polyclonal Antibody
bs-11178R-RBITCSignal Peptide Peptidase Polyclonal Antibody, RBITC Conjugated
bs-11178R-PESignal Peptide Peptidase Polyclonal Antibody, PE Conjugated
bs-11178R-Cy7Signal Peptide Peptidase Polyclonal Antibody, Cy7 Conjugated
bs-11178R-Cy3Signal Peptide Peptidase Polyclonal Antibody, Cy3 Conjugated
bs-11178R-BiotinSignal Peptide Peptidase Polyclonal Antibody, Biotin Conjugated
bs-11178R-PerCPSignal Peptide Peptidase Polyclonal Antibody, PerCP Conjugated
bs-11178R-Cy5Signal Peptide Peptidase Polyclonal Antibody, Cy5 Conjugated
bs-11178R-FITCSignal Peptide Peptidase Polyclonal Antibody, FITC Conjugated

Alternative Products

CatalogName
GTR17730619-01Latency-associated peptide Rabbit Polyclonal Antibody
TMAB-08233-01Anti-Latency-associated peptide Polyclonal Antibody
MBS9463767-01Latency-associated peptide Polyclonal Antibody Bio Conjugated
GTR17762421Latency-associated peptide Rabbit Polyclonal Antibody (Biotin)
GTR18442029Latency-associated peptide Rabbit Polyclonal Antibody (BF405)
GTR18442027Latency-associated peptide Rabbit Polyclonal Antibody (BF555)
GTR17805521Latency-associated peptide Rabbit Polyclonal Antibody (Cy3)
GTR17731573Latency-associated peptide Rabbit Polyclonal Antibody (FITC)
GTR17720929Latency-associated peptide Rabbit Polyclonal Antibody (HRP)
GTR17824302Latency-associated peptide Rabbit Polyclonal Antibody (Cy7)

Popular Products