Etilefrine

CAT: 0804-HY-A0144-01Size: 100 mgDry Ice: NoHazardous: No
CAT#:0804-HY-A0144-01Size:100 mg
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Description
Etilefrine is a sympathetic nerve agonist and AMPK activator that selectively targets α1/β1 adrenergic receptors. Etilefrine stimulates α1 adrenergic receptors, leading to contraction of vascular smooth muscle and increased peripheral resistance. Etilefrine also stimulates β1 receptors to enhance myocardial contractility and increase heart rate, thereby increasing blood pressure and improving cardiac output. Etilefrine also bidirectionally regulates the AMPK/Akt pathway and modulates the phosphorylation levels. Etilefrine can be used in cardiovascular research, such as postural hypotension, chylothorax, and improving low cardiac output[1][2][3].
CAS Number
[709-55-7]
UNSPSC
12352005
Hazard Statement
H302, H312, H315, H319, H332, H335
Target
Adrenergic Receptor; Akt; AMPK
Type
Reference compound
Related Pathways
Epigenetics; GPCR/G Protein; Neuronal Signaling; PI3K/Akt/mTOR
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/etilefrine.html
Purity
97.03
Solubility
DMSO : 40 mg/mL (ultrasonic)
Smiles
OC(CNCC)C1=CC=CC(O)=C1
Molecular Formula
C10H15NO2
Molecular Weight
181.23
Precautions
H302, H312, H315, H319, H332, H335
References & Citations
[1]Chi Xu, et al. Accurate Drug Repositioning through Non-tissue-Specific Core Signatures from Cancer Transcriptomes. Cell Rep. 2018 Oct 9;25 (2) :523-535.e5.|[2]R Yamazaki, et al. Effects of dihydroergotamine and Etilefrine on experimentally-induced postural hypotension in dogs. J Pharmacobiodyn. 1990 Sep;13 (9) :519-24.|[3]Adigun SA, et al. A comparison of the effects of salbutamol, etilefrine and dextran during hypotension and low cardiac output states in rabbit. Clin Exp Pharmacol Physiol. 1984 Nov-Dec;11 (6) :627-43.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
AMPK

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RM-E202001-01Etilefrine Hydrochloride EP Impurity A
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RM-E202004-01Etilefrine hydrochloride EP Impurity D
RM-E202005-01Etilefrine Hydrochloride EP Impurity E

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