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ATG12 Polyclonal Antibody

CAT: 0498-bs-4012R-TRSize: 20 µLDry Ice: NoHazardous: No
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CAT#:0498-bs-4012R-TRSize:20 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Ubiquitin-like protein involved in autophagy vesicles formation. Conjugation with ATG5 through a ubiquitin-like conjugating system involving also ATG7 as an E1-like activating enzyme and ATG1 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. The ATG12-ATG5 conjugate also regulates negatively the innate antiviral immune response by blocking the type I IFN production pathway through direct association with RARRES3 and MAVS. Plays also a role in translation or delivery of incoming viral RNA to the translation apparatus.
Synonyms
APG12; FBR93; APG12L; HAPG12; Ubiquitin-like protein ATG12; Autophagy-related protein 12; APG12-like; ATG12
Gene ID
9140
Swiss Prot
O94817
Cellular Locus
Cytoplasm
Host
Rabbit
Cross Reactivity
Mouse, Rat
Immunogen
101-187/187
Target
ATG12
Clonality
Polyclonal
Conjugation
Unconjugated
Source
KLH conjugated synthetic peptide derived from human ATG12
Applications
WB, ELISA, IHC-P, IHC-F, IF (IHC-P), IF (IHC-F), IF (ICC)
Purification
Purified by Protein A.
Concentration
1ug/ul
Dilution
WB (1:300-5000), ELISA (1:500-1000), IHC-P (1:200-400), IHC-F (1:100-500), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)
Buffer
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Shipped at 4C. Store at -20C for one year. Avoid repeated freeze/thaw cycles.
Prediction Reactivity
Human, Dog, Cow, Pig, Rabbit
Gene ID URL
9140
Isotype
IgG

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