CLEC7A Polyclonal Antibody, FITC Conjugated

• Background:

  Lectin that functions as pattern receptor specific for beta-1,3-linked and beta-1,6-linked glucans, such as cell wall constituents from pathogenic bacteria and fungi. Necessary for the TLR2-mediated inflammatory response and for TLR2-mediated activation of NF-kappa-B. Enhances cytokine production in macrophages and dendritic cells. Mediates production of reactive oxygen species in the cell. Mediates phagocytosis of C.albicans conidia. Binds T-cells in a way that does not involve their surface glycans and plays a role in T-cell activation. Stimulates T-cell proliferation (By similarity) .

• Synonyms:

  BGR; CD369; CANDF4; DECTIN1; CLECSF12; C-type lectin domain family 7 member A; Beta-glucan receptor; C-type lectin superfamily member 12; Dendritic cell-associated C-type lectin 1; DC-associated C-type lectin 1; Dectin-1; CLEC7A; UNQ539/PRO1082

• Gene ID:

  64581

• Swiss Prot:

  Q9BXN2

• Cellular Locus:

  Cell membrane

• Host:

  Rabbit

• Cross Reactivity:

  Human, Mouse, Rat

• Immunogen:

  41-140/247

• Target:

  CLEC7A

• Clonality:

  Polyclonal

• Conjugation:

  FITC

• Source:

  KLH conjugated synthetic peptide derived from human Beta-glucan receptor

• Applications:

  WB, FCM

• Purification:

  Purified by Protein A.

• Excitation Emission:

  494nm/518nm

• Concentration:

  1ug/ul

• Dilution:

  WB (1:300-5000), FCM (1:20-100)

• Buffer:

  Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

• Modification:

  Unmodified

• Storage Conditions:

  Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

• Gene ID URL:

  64581

• Isotype:

  IgG