DUSP5 Polyclonal Antibody

• Background:

  Dual specificity phosphatases (DSPs) are a subclass of the protein tyrosine phosphatase (PTP) gene superfamily, which are selective for dephosphorylating critical phosphothreonine and phosphotyrosine residues within MAP kinases. DSP gene expression is induced by a host of growth factors and/or cellular stresses, thereby negatively regulating MAP kinase superfamily members including MAPK/ERK, SAPK/JNK and p38. The members of the dual-specificity phosphatase protein family include MKP-1/CL100 (3CH134), MKP-2, MKP-3, MKP-4, MKP-5, MKP-6, MKP-7, MKP-X, VHR, VHY, PAC1, hVH-3 (B23), hVH-5, PYST2, DUSP1, DUSP5, DUSP8, PIR1 and SKRP1. DUSP5 is a nuclear phosphoprotein that displays phosphatase activity toward several different substrates. It shows the highest relative activity toward ERK1.

• Synonyms:

  Dual specicity protein phosphatase 5; Dual specicity protein phosphatase hVH 3; Dual specicity protein phosphatase hVH3; DUSP 5; DUSP; HVH 3; HVH3; Serine/threonine specic protein phosphatase; VH 3; VH1 like phosphatase 3; VH3; DUS5_HUMAN.

• Gene ID:

  1847

• Cellular Locus:

  Nucleus

• Host:

  Rabbit

• Cross Reactivity:

  Mouse, Rat

• Immunogen:

  221-320/384

• Target:

  DUSP5

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Source:

  KLH conjugated synthetic peptide derived from human DUSP5

• Applications:

  WB, ELISA, IHC-P, IHC-F, IF (IHC-P), IF (IHC-F), IF (ICC)

• Purification:

  Purified by Protein A.

• Concentration:

  1ug/ul

• Dilution:

  WB (1:300-5000), ELISA (1:500-1000), IHC-P (1:200-400), IHC-F (1:100-500), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)

• Buffer:

  0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

• Modification:

  Unmodified

• Storage Conditions:

  Shipped at 4C. Store at -20C for one year. Avoid repeated freeze/thaw cycles.

• Prediction Reactivity:

  Human

• Gene ID URL:

  1847

• Isotype:

  IgG