NPC2 Polyclonal Antibody

• Background:

  NPC2 is a secreted protein mapping against gene 14q24.3 (1,2) . NPC2 regulates the lipid composition of sperm membranes during maturation in the epididymis (1,2) . Mutations in the NPC2 gene may cause Nieman-Pick type C2 disease and frontal lobe atrophy (1,2,3) . Nieman-Pick type C2 is a fatal hereditary disease characterized by defective lysosome release of cholesterol (3) . The disease is caused by HE1 deficiency, a lysosmal protein proven to be undetectable in fibroblasts from NPC2 patients (3) . This differentiates NPC2 from NPC1, as NPC1 has HE1 protein present (3) .

• Synonyms:

  EDDM1; Epididymal protein 1; Epididymal secretory protein; Epididymal secretory protein E1; HE1; Human epididymis-specic protein 1; Niemann-Pick disease type C2; Niemann-Pick disease type C2 protein; NPC2; NPC2_HUMAN; Tissue specic secretory protein.

• Cellular Locus:

  Cytoplasm, Secreted

• Host:

  Rabbit

• Cross Reactivity:

  Human

• Immunogen:

  20-80/151

• Target:

  NPC2

• Clonality:

  Polyclonal

• Conjugation:

  Unconjugated

• Source:

  KLH conjugated synthetic peptide derived from human Niemann Pick C2

• Applications:

  WB, ELISA

• Purification:

  Purified by Protein A.

• Concentration:

  1ug/ul

• Dilution:

  WB (1:300-5000), ELISA (1:500-1000)

• Buffer:

  0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

• Modification:

  Unmodified

• Storage Conditions:

  Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

• Prediction Reactivity:

  Mouse, Rat, Cow, Sheep

• Isotype:

  IgG