NPC2 Polyclonal Antibody

CAT: 0498-bs-11736R-TRSize: 20 µLDry Ice: NoHazardous: No
CAT#:0498-bs-11736R-TRSize:20 µL
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PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
NPC2 is a secreted protein mapping against gene 14q24.3 (1,2) . NPC2 regulates the lipid composition of sperm membranes during maturation in the epididymis (1,2) . Mutations in the NPC2 gene may cause Nieman-Pick type C2 disease and frontal lobe atrophy (1,2,3) . Nieman-Pick type C2 is a fatal hereditary disease characterized by defective lysosome release of cholesterol (3) . The disease is caused by HE1 deficiency, a lysosmal protein proven to be undetectable in fibroblasts from NPC2 patients (3) . This differentiates NPC2 from NPC1, as NPC1 has HE1 protein present (3) .
Synonyms
EDDM1; Epididymal protein 1; Epididymal secretory protein; Epididymal secretory protein E1; HE1; Human epididymis-specic protein 1; Niemann-Pick disease type C2; Niemann-Pick disease type C2 protein; NPC2; NPC2_HUMAN; Tissue specic secretory protein.
Cellular Locus
Cytoplasm, Secreted
Host
Rabbit
Cross Reactivity
Human
Immunogen
20-80/151
Target
NPC2
Clonality
Polyclonal
Conjugation
Unconjugated
Source
KLH conjugated synthetic peptide derived from human Niemann Pick C2
Applications
WB, ELISA
Purification
Purified by Protein A.
Concentration
1ug/ul
Dilution
WB (1:300-5000), ELISA (1:500-1000)
Buffer
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
Prediction Reactivity
Mouse, Rat, Cow, Sheep
Isotype
IgG

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