FL118

• Description:

  FL118 (10,11- (Methylenedioxy) -20 (S) -camptothecin), a Camptothecin (HY-16560) analogue, is a potent and orally active survivin inhibitor. FL118 binds to oncoprotein DDX5 (p68) to dephosphorylates and degrades DDX5. FL118 can be used for the research of cancer[1][2].

• Product Name Alternative:

  10,11- (Methylenedioxy) -20 (S) -camptothecin

• UNSPSC:

  12352005

• Hazard Statement:

  H301+H311+H331

• Target:

  Apoptosis; IAP; Survivin

• Type:

  Reference compound

• Related Pathways:

  Apoptosis

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/fl118.html

• Purity:

  99.40

• Solubility:

  DMSO : 1 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles:

  O=C1[C@](O)(CC)C(C=C2C3=NC4=CC5=C(C=C4C=C3CN2C6=O)OCO5)=C6CO1

• Molecular Formula:

  C21H16N2O6

• Molecular Weight:

  392.36

• Precautions:

  H301+H311+H331

• References & Citations:

  [1]Zhao H, et al. FL118, a novel anticancer compound, inhibits proliferation and migration of ovarian cancer cells via up-regulation of cytoglobin in vivo and in vitro[J]. Translational Cancer Research, 2017, 6 (6) :1294-1304.|[2]Ling X, et al. FL118, acting as a 'molecular glue degrader', binds to dephosphorylates and degrades the oncoprotein DDX5 (p68) to control c-Myc, survivin and mutant Kras against colorectal and pancreatic cancer with high efficacy. Clin Transl Med. 2022 May;12 (5) :e881.|[3]Wu G, et al. Synthesis of novel 10,11-methylenedioxy-camptothecin glycoside derivatives and investigation of their anti-tumor effects in vivo. RSC Adv. 2019 Apr 9;9 (20) :11142-11150. |[4]Ling X, et, al. FL118, a novel camptothecin analogue, overcomes irinotecan and topotecan resistance in human tumor xenograft models. Am J Transl Res. 2015 Oct 15;7 (10) :1765-81.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  Phase 1

• CAS Number:

  [135415-73-5]