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Netrin 4 Polyclonal Antibody

CAT: 0498-bs-10065R-TRSize: 20 µLDry Ice: NoHazardous: No
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CAT#:0498-bs-10065R-TRSize:20 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Netrin proteins are a family of laminin-related secreted proteins that provide guidance signals for axonal growth and cell migration during development. Netrin signaling is dependent on the concentration of calcium outside the cell and the level of PKA activity. In axonal cells, a reduction in PKA activity converts the responsiveness of the axons to the netrin proteins, as the cells are repelled, rather than attracted, by the netrin gradient. Netrin-4 is related to the Laminin chains, and is therefore also designated -netrin. It is present in the basement membranes of the vasculature, lateral olfactory tract, kidney and ovary. In humans, the gene encoding for the netrin-4 protein is localized to chromosome 12q22-q23. High levels of netrin-4 mRNA have also been detected in many cells and tissues, including cerebral cortex, hippocampus, amygdaloid nuclei and Purkinje cells. Netrin-4 is important in neural, kidney and vascular development.
Synonyms
Beta netrin; Beta-netrin; Hepar derived netrin like protein; Hepar-derived netrin-like protein; NET4_HUMAN; Netrin-4; Netrin4; NTN 4; NTN4.
Gene ID
59277
Cellular Locus
Secreted, Cell membrane, Extracellular matrix
Host
Rabbit
Cross Reactivity
Others
Immunogen
520-628/628
Target
Netrin 4
Clonality
Polyclonal
Conjugation
Unconjugated
Source
KLH conjugated synthetic peptide derived from human Netrin 4
Applications
WB, ELISA, IHC-P, IHC-F, IF, ICC/IF
Purification
Purified by Protein A.
Concentration
1ug/ul
Dilution
WB (WB=1:500-2000), ELISA (ELISA=1:5000-10000), IHC-P (IHC-P=1:100-500), IHC-F (IHC-F=1:100-500), IF (IF=1:100-500), ICC/IF (ICC/IF=1:100-500)
Buffer
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Shipped at 4C. Store at -20C for one year. Avoid repeated freeze/thaw cycles.
Prediction Reactivity
Human, Mouse, Rat, Dog, Cow, Pig, Horse, Rabbit
Gene ID URL
59277
Isotype
IgG

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