NFKB2 Polyclonal Antibody

CAT: 0498-bs-10037R-TRSize: 20 µLDry Ice: NoHazardous: No
CAT#:0498-bs-10037R-TRSize:20 µL
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Background
This gene encodes a subunit of the transcription factor complex nuclear factor-kappa-B (NFkB) . The NFkB complex is expressed in numerous cell types and functions as a central activator of genes involved in inflammation and immune function. The protein encoded by this gene can function as both a transcriptional activator or repressor depending on its dimerization partner. The p100 full-length protein is co-translationally processed into a p52 active form. Chromosomal rearrangements and translocations of this locus have been observed in B cell lymphomas, some of which may result in the formation of fusion proteins. There is a pseudogene for this gene on chromosome 18. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]
Synonyms
P52; p100; H2TF1; LYT10; CVID10; LYT-10; NF-kB2; Nuclear factor NF-kappa-B p100 subunit; DNA-binding factor KBF2; Lymphocyte translocation chromosome 10 protein; Nuclear factor of kappa light polypeptide gene enhancer in B-cells 2; Oncogene Lyt-10; NFKB2
Gene ID
4791
Swiss Prot
Q00653
Cellular Locus
Cytoplasm, Nucleus
Host
Rabbit
Cross Reactivity
Human, Mouse
Immunogen
151-250/900
Target
NFKB2
Clonality
Polyclonal
Conjugation
Unconjugated
Source
KLH conjugated synthetic peptide derived from human NFKB p52
Applications
ELISA, FCM, IHC-P, IHC-F, IF (IHC-P), IF (IHC-F), IF (ICC)
Purification
Purified by Protein A.
Concentration
1ug/ul
Dilution
ELISA (1:500-1000), FCM (1:20-100), IHC-P (1:200-400), IHC-F (1:100-500), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)
Buffer
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
Specificity
The immunoge used to produce this antibody has 83% sequence similarity with NFKB p105/ p50
Prediction Reactivity
Rat, Dog, Cow, Pig, Horse, Chicken
Gene ID URL
4791
Isotype
IgG

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