PALB2 Polyclonal Antibody

CAT: 0498-bs-0588R-TRSize: 20 µLDry Ice: NoHazardous: No
CAT#:0498-bs-0588R-TRSize:20 µL
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Background
Plays a critical role in homologous recombination repair (HRR) through its ability to recruit BRCA2 and RAD51 to DNA breaks. Strongly stimulates the DNA strand-invasion activity of RAD51, stabilizes the nucleoprotein filament against a disruptive BRC3-BRC4 polypeptide and helps RAD51 to overcome the suppressive effect of replication protein A (RPA) . Functionally cooperates with RAD51AP1 in promoting of D-loop formation by RAD51. Serves as the molecular scaffold in the formation of the BRCA1-PALB2-BRCA2 complex which is essential for homologous recombination. Via its WD repeats is proposed to scaffold a HR complex containing RAD51C and BRCA2 which is thought to play a role in HR-mediated DNA repair. Essential partner of BRCA2 that promotes the localization and stability of BRCA2. Also enables its recombinational repair and checkpoint functions of BRCA2. May act by promoting stable association of BRCA2 with nuclear structures, allowing BRCA2 to escape the effects of proteasome-mediated degradation. Binds DNA with high affinity for D loop, which comprises single-stranded, double-stranded and branched DNA structures. May play a role in the extension step after strand invasion at replication-dependent DNA double-strand breaks; together with BRCA2 is involved in both POLH localization at collapsed replication forks and DNA polymerization activity.
Synonyms
FANCN; PNCA3; Partner and localizer of BRCA2; PALB2
Gene ID
79728
Swiss Prot
Q86YC2
Cellular Locus
Nucleus
Host
Rabbit
Cross Reactivity
Human, Pig
Immunogen
1101-1186/1186
Target
PALB2
Clonality
Polyclonal
Conjugation
Unconjugated
Source
KLH conjugated synthetic peptide derived from human PALB2
Applications
WB, ELISA, FCM, IHC-P, IHC-F, IF (IHC-P), IF (IHC-F), IF (ICC)
Purification
Purified by Protein A.
Concentration
1ug/ul
Dilution
WB (1:300-5000), ELISA (1:500-1000), FCM (1:20-100), IHC-P (1:200-400), IHC-F (1:100-500), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)
Buffer
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Modification
Unmodified
Storage Conditions
Shipped at 4C. Store at -20C for one year. Avoid repeated freeze/thaw cycles.
Prediction Reactivity
Mouse, Rat, Cow
Gene ID URL
79728
Isotype
IgG

Related Products

CatalogName
bs-42066P-01Recombinant human PALB2 protein
bs-42066P-Biotin-01Recombinant human PALB2 protein, Biotin Conjugated
bs-42066P-APC-01Recombinant human PALB2 protein, APC Conjugated
bs-9028R-01AKAP2/PALM2 Polyclonal Antibody
bs-9028R-TRAKAP2/PALM2 Polyclonal Antibody
bs-9028R-BiotinAKAP2/PALM2 Polyclonal Antibody, Biotin Conjugated
bs-9028R-FITCAKAP2/PALM2 Polyclonal Antibody, FITC Conjugated
bs-9028R-PerCPAKAP2/PALM2 Polyclonal Antibody, PerCP Conjugated
bs-9028R-RBITCAKAP2/PALM2 Polyclonal Antibody, RBITC Conjugated
bs-9028R-PEAKAP2/PALM2 Polyclonal Antibody, PE Conjugated

Alternative Products

CatalogName
E98373PALB2 Polyclonal Antibody
APR06555GPolyclonal PALB2 Antibody
TA306814PALB2 Rabbit Polyclonal Antibody
NB100-60440Rabbit Polyclonal PALB2 Antibody
MF-0082359-01Anti-PALB2 Polyclonal Antibody
NB100-60440FRabbit Polyclonal PALB2 Antibody [FITC]
NB100-60440HRabbit Polyclonal PALB2 Antibody [HRP]
MBS7128081-01PALB2 Antibody

Popular Products