PP2A alpha + beta Polyclonal Antibody

• Background :

  PP2A is the major phosphatase for microtubule-associated proteins (MAPs) . PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase. Cooperates with SGOL2 to protect centromeric cohesin from separase-mediated cleavage in oocytes specifically during meiosis I (By similarity) . Can dephosphorylate SV4 large T antigen and p53/TP53. Activates RAF1 by dephosphorylating it at 'Ser-259'.

• Synonyms :

  RP-C; PP2Ac; PP2CA; PP2Calpha; Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform; PP2A-alpha; Replication protein C; PPP2CA

• Gene ID :

  5515

• Swiss Prot :

  P67775

• Cellular Locus :

  Cytoplasm, Nucleus

• Host :

  Rabbit

• Cross Reactivity :

  Human, Mouse, Rat

• Immunogen :

  205-309/309

• Target :

  PP2A alpha + beta

• Clonality :

  Polyclonal

• Conjugation :

  Unconjugated

• Source :

  KLH conjugated synthetic peptide derived from human PP-2A

• Applications :

  WB, ELISA, FCM, IHC-P, IHC-F, IF (IHC-P), IF (IHC-F), IF (ICC)

• Purification :

  Purified by Protein A.

• Concentration :

  1ug/ul

• Dilution :

  WB (1:300-5000), ELISA (1:500-1000), FCM (1:20-100), IHC-P (1:200-400), IHC-F (1:100-500), IF (IHC-P) (1:50-200), IF (IHC-F) (1:50-200), IF (ICC) (1:50-200)

• Buffer :

  0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

• Modification :

  Unmodified

• Storage Conditions :

  Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

• Prediction Reactivity :

  Dog, Cow, Pig, Chicken, Rabbit

• Gene ID URL :

  5515

• Isotype :

  IgG