API2/BIRC3 Recombinant Antibody

• Background:

  Multi-functional protein which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling and cell proliferation, as well as cell invasion and metastasis. Acts as an E3 ubiquitin-protein ligase regulating NF-kappa-B signaling and regulates both canonical and non-canonical NF-kappa-B signaling by acting in opposite directions: acts as a positive regulator of the canonical pathway and suppresses constitutive activation of non-canonical NF-kappa-B signaling.

• Synonyms:

  AIP1; API2; BIRC3; CIAP2; HAIP1; IAP homolog C ; RNF49; MIHC; MALT2; Apoptosis inhibitor 2; IAP2.

• Gene ID:

  330

• Swiss Prot:

  Q13489

• Cellular Locus:

  Cytoplasm, Nucleus

• Host:

  Rabbit

• Cross Reactivity:

  Human

• Target:

  API2/BIRC3

• Clonality:

  Recombinant

• Isotype:

  IgG

• Conjugation:

  Unconjugated

• Source:

  KLH conjugated synthetic peptide derived from human BIRC3

• Applications:

  WB, IHC-P, IHC-F, IP, IF, ICC/IF

• Purification:

  Purified by Protein A.

• Concentration:

  Lot dependent

• Dilution:

  WB (1:300-5000), IHC-P (1:200-400), IHC-F (1:100-500), IP (1-2ug), IF (), ICC/IF (1:50-100)

• Buffer:

  0.01M TBS (pH 7.4), 1% BSA, 0.02% Proclin 300, and 50% Glycerol

• Modification:

  Unmodified

• Storage Conditions:

  Shipped at 4C. Store at -20C for one year. Avoid repeated freeze/thaw cycles.

• Gene ID URL:

  330