Stat3 Recombinant Antibody

• Background:

  Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6) -responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA. Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity. Plays an important role in host defense in methicillin-resistant S.aureus lung infection by regulating the expression of the antimicrobial lectin REG3G (By similarity) .

• Synonyms:

  APRF; HIES; ADMIO; Signal transducer and activator of transcription 3; Acute-phase response factor; STAT3

• Gene ID:

  6774

• Swiss Prot:

  P40763

• Host:

  Rabbit

• Cross Reactivity:

  Human, Mouse, Rat

• Target:

  Stat3

• Clonality:

  Recombinant

• Isotype:

  IgG

• Conjugation:

  Unconjugated

• Source:

  Recombinant human Stat3 protein, around N-terminal 1-100aa.

• Applications:

  WB, IHC-P, IHC-F, IF, Flow-Cyt, ICC/IF

• Purification:

  Purified by Protein A.

• Concentration:

  Lot dependent

• Dilution:

  WB (1:300-5000), IHC-P (1:200-400), IHC-F (1:100-500), IF (), Flow-Cyt (1ug/Test), ICC/IF (1:50-100)

• Buffer:

  0.01M TBS (pH 7.4), 1% BSA, 0.02% Proclin 300, and 50% Glycerol

• Modification:

  Unmodified

• Storage Conditions:

  Shipped at 4°. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

• Gene ID URL:

  6774