Senexin B

CAT: 0498-bs-83815C-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0498-bs-83815C-01Size:5 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Background

Senexin B is a potent inhibitor of cyclin-dependent kinases 8 and 19.1 It suppressed tumor growth and augmented the effects of fulvestrant in ER-positive breast cancer xenografts. KD50s: CDK8 = 59 nM, CDK19 = 23 nM.2 Senexin B also showed synergistic effects with lapatinib and trastuzumab in a panel of HER2+ breast cancer cell lines. Senexin B and ALK5 inhibitor SB431542 afforded generation of pancreatic islet cells from pluripotent stem cells without any mutagenic effects.4 Combination treatment of Senexin B and Imatinib intensified apoptotic cell death in chronic myelogenous leukemia cells and prevented quiescence-mediated escape from apoptosis.5

Conjugation

Unconjugated

Buffer

Off-white solid

Storage Conditions

-20°C

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Senexin B

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