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PK11007

CAT: 0498-bs-83759C-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0498-bs-83759C-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
PK11007 reactivates mutant p53 via selective alkylation of two cysteine residues without compromising DNA-binding ability.1 p53 target genes p21 and PUMA were activated by treatment with PK11007. Mutant p53-containing cancer cells were more sensitive to PK11007 than wild-type with mutant cells showing greatly reduced viability. It also generated high levels of reactive oxygen species and induced ER stress in a p53-independent (and dependent on glutathione depletion) manner that resulted in cell death. PK11007 inhibited cellular proliferation, induced apoptosis, and blocked cell migration in a panel of 17 breast cancer lines including triple-negative breast cancer (IC50s: 2.3 to 42.2 µM) .2
Conjugation
Unconjugated
Buffer
White solid
Storage Conditions
-20°C

Alternative Products

CatalogName
BA3464-10PK11007
A16833-25PK11007 25mg
A16833-50PK11007 50mg
A16833-10PK11007 10mg
A16833-5PK11007 5mg
A16833-100PK11007 100mg
TBI4176-25MGPK11007, Reactivator of mutant p53

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