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DMB

CAT: 0498-bs-83743C-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0498-bs-83743C-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
DMB is a small molecule glucagon-like peptide 1 (GLP-1) ago-allosteric modulator and agonist (EC50 = 101 nM) .1 It significantly stimulated insulin secretion in BRIN-BD11 cells and decreased overall glucose excursion in mice.2 DMB is a direct and selective gasdermin D (GSDMD) agonist that activates GSDMD pore formation and pyroptosis without cleaving GSDMD (EC50 = 700 nM) .3 It induced pyroptosis in mouse cancer cell lines and induced tumor regression and enhanced antitumor immunity. DMB-treated tumor cells acted as a tumor vaccine in mice indicating that DMB can trigger immunogenic cell death that provides protective antitumor immunity.
Conjugation
Unconjugated
Buffer
Yellow solid
Storage Conditions
-20°C

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