BMH-21

CAT: 0498-bs-83455C-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0498-bs-83455C-01Size:5 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
A planar heterocyclic DNA intercalator that inhibits RNA polymerase I (Pol I), IC50 = 0.6 µM in U2OS cells, but not Pols II or III, blocking transcription elongation without inducing the DNA damage response.1-3 Inhibition disengages Pol I from chromatin, resulting in proteasome-dependent destruction of Pol I subunit RPA194.4 At nanomolar concentrations it also activates p53 in A375 cells.5
Conjugation
Unconjugated
Buffer
Orange solid
Storage Conditions
-20°C

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