BMH-21

• Background:

  A planar heterocyclic DNA intercalator that inhibits RNA polymerase I (Pol I), IC50 = 0.6 µM in U2OS cells, but not Pols II or III, blocking transcription elongation without inducing the DNA damage response.1-3 Inhibition disengages Pol I from chromatin, resulting in proteasome-dependent destruction of Pol I subunit RPA194.4 At nanomolar concentrations it also activates p53 in A375 cells.5

• Conjugation:

  Unconjugated

• Buffer:

  Orange solid

• Storage Conditions:

  -20°C