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Ponatinib

CAT: 0498-bs-83426C-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0498-bs-83426C-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Highly potent pan-Bcr-Abl and multikinase inhibitor, suppressing the activity of native Bcr-Abl (IC50=0.37 nM) as well as the mutants T315I (IC50=2 nM), Q252H (IC50=0.44 nM), Y253F (IC50=0.3 nM), M351T (IC50=0.3 nM) and H396P (IC50=0.34 nM) .1 Also inhibits PDGFR, c-Src and c-Kit (IC50=1.1, 5.4 and 12.5 nM respectively) 2 as well as FGFR-mediated signaling (IC50<40 nM) 3. Protects against influenza A virus-induced death by suppressing cytokine storm in mouse models.4
Conjugation
Unconjugated
Buffer
Yellow solid
Storage Conditions
-20°C

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CatalogName
202320Ponatinib

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