Ponatinib

• Background:

  Highly potent pan-Bcr-Abl and multikinase inhibitor, suppressing the activity of native Bcr-Abl (IC50=0.37 nM) as well as the mutants T315I (IC50=2 nM), Q252H (IC50=0.44 nM), Y253F (IC50=0.3 nM), M351T (IC50=0.3 nM) and H396P (IC50=0.34 nM) .1 Also inhibits PDGFR, c-Src and c-Kit (IC50=1.1, 5.4 and 12.5 nM respectively) 2 as well as FGFR-mediated signaling (IC50<40 nM) 3. Protects against influenza A virus-induced death by suppressing cytokine storm in mouse models.4

• Conjugation:

  Unconjugated

• Buffer:

  Yellow solid

• Storage Conditions:

  -20°C