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ICRF-193

CAT: 0498-bs-83425C-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0498-bs-83425C-01Size:1 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
ICRF-193 is a topoisomerase II poison.1 Toposiomerase poisons are a special subclass of topoisomerase inhibitors that stabilize topoisomerase-DNA strand passing intermediates and thus cause the topoisomerases to become a cytotoxic DNA-damaging agent.1 It readily induces DNA strand breaks in V79 and irs-2 Chinese hamster lung fibroblasts via a novel mechanism.2 Displays cardioprotective (against anthracycline toxicity) 3 and anti-inflammatory effects via reduction of IL-1β secretion by macrophages4. An important tool for studying the cellular response to DNA double-strand breaks.5
Conjugation
Unconjugated
Buffer
Off-white solid
Storage Conditions
-20°C

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