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Ibrutinib

CAT: 0498-bs-83411C-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0498-bs-83411C-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Ibrutinib (936563-96-1) is a very potent (IC50 = 0.5nM) irreversible inhibitor of Bruton tyrosine kinase (BTK) that blocks activation of the B-cell antigen receptor (BCR) .1 Ibrutinib also potently inhibits several other kinases including BLK, BMS, FGR, EGFR, and ITK. It is a clinically useful drug to treat B cell cancers. It inhibits CLL cell migration and survival2,3 and downregulates expression of CD204. It enhanced antitumor immune responses in combination with anti PD-L1 blockade via its inhibition of ITK (IL2-inducible T-cell kinase) .5
Conjugation
Unconjugated
Buffer
White or off-white solid
Storage Conditions
-20°C

Alternative Products

CatalogName
HY-10997-01Ibrutinib

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