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AGI-5198

CAT: 0498-bs-83401C-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0498-bs-83401C-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
AGI-5198 is a potent (IC50 = 70 nM) inhibitor of mutant isocitrate dehydrogenase 1 (IDH1) .1 It is selective for the R132H-IDH1 mutant and does not affect wild type cells.2 This mutation results in loss-of-function for oxidative decarboxylation of isocitrate and gain-of-function for production of the oncometabolite R-2-hydroxyglutarate (R-2HG) form alpha-ketoglutarate (2-OG) .
Conjugation
Unconjugated
Buffer
White solid
Storage Conditions
-20°C

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