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SAG

CAT: 0498-bs-83398C-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0498-bs-83398C-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Smoothened agonist which bind directly to SMO and can block SMO inhibition by cyclopamine. The conformation of SMO is altered by SAG binding which results in the accumulation of SMO in cilia and activated gene transcription. It should be noted that SAG inhibits hedgehog signaling at concentrations greater than 1 µM (EC50 for SMO activation is ~ 3 nM) .1
Conjugation
Unconjugated
Buffer
Off-white solid
Storage Conditions
-20°C

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