Products for Research Use Only
RegisterLogin

PK150

CAT: 0498-bs-83369C-01Size: 10 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0498-bs-83369C-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Background
PK150 is a Sorafenib analog that displays significant antibacterial activity against several pathogenic strains (S.aureus NCTC8325, MIC = 0.3 µM; vancomycin -resistant enterococci, MIC = 3 µM; and M.tuberculosis MIC = 2 µM) . It was inactive against Gram-negative bacteria. It effectively reduced persister cells in ciprofloxacin-treated stationary S.aureus cultures and effectively eradicated staphylococcus biofilms. PK150 did not develop antibacterial resistance in an agar-plate-based assay. Its antibacterial properties were attributed to demethylmenaquinone methyltransferase (MenG) inhibition and signal peptidase IB (SpsB) activation. PK150 displayed in vivo efficacy in a murine bloodstream infection model against methicillin-sensitive S. aureus and a neutropenic mouse thigh model against methicillin-resistant S. aureus strain ATCC33591. Inactive against a panel of over 250 human kinases.
Conjugation
Unconjugated
Buffer
White solid
Storage Conditions
-20°C

Alternative Products

CatalogName
GTR19167293-01PK150
GW6750-5mgPK150 (Sorafenib Analog)
10463033Syringe Filter for AKTA 0.45um - PK150
10463043Syringe Filter for AKTA 0.2um - PK150
FIL2559Whatman GDX 13mm CA 0.45um - PK150
FIL4168Whatman GDX 25mm PP 0.2um - PK150
FIL4170Whatman GDX 25mm PP 0.45um - PK150
FIL2557Whatman GDX 13mm PP 0.45um - PK150
FIL2555Whatman GDX 13mm PP 0.2um - PK150

Popular Products