Ophiobolin

• Background :

  Selectively inhibits the growth of cancer cells (IC50=0.4-4.3 M) over normal cells (IC50=20.9 M) .1 Induces non-apoptotic cell death in glioblastoma cells and is active in an in vivo model.2 Covalently reacts with primary amines such as lysine side chains2 and phosphatidylethanolamine3 forming unique pyrrole adducts. Induces ER stress4, paraptosis4 and autophagy5.

• Conjugation :

  Unconjugated

• Buffer :

  White solid

• Storage Conditions :

  -20°C