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PP242

CAT: 0498-bs-83326C-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0498-bs-83326C-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
PP242 is an ATP-competitive mTORC1/mTORC2 inhibitor (IC50 = 8 nM) displaying high selectivity over PI 3K family kinases (IC50s =0.102 to 2.2 μM) and modest selectivity over PKC family kinases (IC50s =0.049 to 0.198 μM) .1,2 PP 242 (but not rapamycin) induced the death of mouse and human leukemia cells but was much weaker than rapamycin at induction of death of normal lymphocytes.3 Restores lysosomal activity and facilitates clearance of amyloid-β in a mouse model of dry age-related macular degeneration.4 Inhibits glioblastoma cell proliferation, migration, invasiveness, and stemness.5
Conjugation
Unconjugated
Buffer
Off-white to beige solid
Storage Conditions
-20°C

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