Vandetanib

• Background :

  A potent and selective inhibitor of VEGFR2, (KDR IC50 = 40 nM) . Also inhibits fms-like tyrosine kinase 4 (VEGFR3, IC50 = 110 nM) and epidermal growth factor receptor (EGFR/HER1, IC50 = 500 nM) but shows selectivity against a panel of other tyrosine and serine-threonine kinases. Inhibits colony formation in seven cancer cell lines2. Displays anti-angiogenesis activity3.

• Conjugation :

  Unconjugated

• Buffer :

  White or off-white solid

• Storage Conditions :

  -20°C