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SM-164

CAT: 0498-bs-83122C-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0498-bs-83122C-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Cell-permeable Smac (DIABLO) mimetic that inhibits caspase blockers XIAP, cIAP1, and cIAP2 (Ki = 36, <1, and <1.9 nM), thus inducing apoptosis.1-3 SM-164 sensitizes cancer cells to DNA damaging agents.4 It also prevents binding of Hsp70 to XIAP.5 At high concentrations, it causes lytic cell death that is neither apoptosis nor necroptosis.6
Conjugation
Unconjugated
Buffer
White to pale-yellow solid
Storage Conditions
-20°C

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