Biotin-isoxazole

CAT: 0498-bs-83117C-01Size: 1 mgDry Ice: NoHazardous: No

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CAT#:0498-bs-83117C-01Size:1 mg

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Background

Exposure of cell or tissue lysates to biotin-isoxazole precipitates hundreds of RNA-binding proteins with significant overlap to the constituents of RNA granules.1,2 In one study roughly 580 nuclear proteins were identified as being precipitated by B-Isox including TAF15, RNA polymerase II (largest subunit), numerous subunits of the mediator complex as well as a variety of enzymes involved in epigenetic modification of histones.3 SR domains were found to be the determinant that facilitates B-Isox precipitation.4 Also allows for the fractionation / isolation of SG-associated proteins and RNA precipitates.5

Conjugation

Unconjugated

Buffer

Beige solid

Storage Conditions

-20°C

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GTR19154410-01	Biotin-isoxazole
BA1123-50000	Isoxazole
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239045-01	Isoxazole 99+%
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Biotin-isoxazole

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