PSB-1584

CAT: 0498-bs-83111C-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0498-bs-83111C-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
GPR84 is an orphan G protein-coupled receptor that is activated by medium-chain fatty acids and hydroxyfatty acids although these may not be its endogenous agonist.1 It is highly expressed on immune cells and expression levels rise after exposure to inflammatory stimuli.2 Potent synthetic agonists enhance proinflammatory signaling and macrophage effector functions.1 PSB-1584 is a potent synthetic exogenous agonist at GPR84, EC50=5 nM which is selective against other free fatty acid receptors and is metabolically stable when incubated with human liver microsomes.3 An important new tool for studying the physiology of GPR84.4
Conjugation
Unconjugated
Buffer
Off-white solid
Storage Conditions
-20°C

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