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OSS-128167

CAT: 0498-bs-83100C-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0498-bs-83100C-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
OSS-128167 (887686-02-4) is an inhibitor of SIRT6 (IC50=89 µM) showing selectivity over SIRT1 and SIRT2 (IC50s=1,578 and 751 µM, respectively) .1 In diffuse large B-cell lymphoma cells which overexpress SIRT6, treatment with OSS-128167 resulted in higher rates of apoptosis, arrested cell cycle progression and augmented sensitivity to chemotherapy.2 It exacerbates diabetic cardiomyopathy by aggravating inflammation and oxidative stress in a streptozotocin-induced diabetic mouse model3 and delays peripheral nerve recovery after injury by suppressing migration, phagocytosis and M2-polarization of macrophages4. OSS-128167 promotes cell senescence and aging in myocardial H9c2 cells.5
Conjugation
Unconjugated
Buffer
Off-white solid
Storage Conditions
-20°C

Alternative Products

CatalogName
B2761-5OSS-128167
A17048-50OSS-128167 50mg
A17048-10OSS-128167 10mg
A17048-500OSS-128167 500mg
A17048-100OSS-128167 100mg
A17048-2OSS-128167 2mg
A17048-25OSS-128167 25mg
A17048-5OSS-128167 5mg
A17048-1OSS-128167 1mg
TBI5197-25MGOSS-128167, SIRT6 inhibitor

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