Fludarabine

CAT: 0498-bs-83082C-01Size: 10 mgDry Ice: NoHazardous: No

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CAT#:0498-bs-83082C-01Size:10 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Background

A synthetic adenosine analog that inhibits DNA biosynthesis and is a clinically useful antineoplastic agent.1 In cells fludarabine accumulates as its 5’-triphosphate (F-ara-ATP) for which the rate-limiting step in formation is the conversion of fludarabine to its monophosphate.2 F-ara-ATP has multiple mechanisms of action including inhibition of ribonucleotide reductase, DNA polymerase, ligase and primase.2 A frequently used agent in myeloablative conditioning regimens for allogeneic hematopoietic cell transplantation.3 Immunosuppressive effects are mediated via inhibition of TNF-stimulated production of IL-2 and IFN- through inactivation of NFB.4 Antagonist at adenosine A1 receptors.5

Conjugation

Unconjugated

Buffer

White solid

Storage Conditions

-20°C

Alternative Products

Catalog	Name
T1038-01	Fludarabine

Fludarabine

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