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ML792

CAT: 0498-bs-83078C-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0498-bs-83078C-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
ML792 is a potent (IC50’s = 3 nM SUMO1; 11 nM SUMO2) and selective (IC50 = 32 µM for NEDD8-activating enzyme (NAE) ) mechanism-based inhibitor of SUMO-activating enzyme (SAE) .1 Treatment of multiple cancer cell lines led to failure of mitotic progression and induction of endoreduplication with MYC-amplified cell lines showing higher sensitivity. ML792 inhibited B-cell growth and promoted cell death in Epstein-Barr virus (EBV) -positive B cells and nasopharyngeal carcinoma cells. It also modulated Latent Membrane Protein-1-induced cell migration and cell adhesion suggesting therapeutic potential in treating EBV-associated malignancies.2
Conjugation
Unconjugated
Buffer
White solid
Storage Conditions
-20°C

Alternative Products

CatalogName
abx283424-01ML792
TBI4985-5MGML792, SUMO-activating enzyme (SAE) inhibitor

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