Dp44mT

CAT: 0498-bs-83068C-01Size: 5 mgDry Ice: NoHazardous: No

1 / 1

CAT#:0498-bs-83068C-01Size:5 mg

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

Quick Request Actions

Background

Dp44mT is a metal chelator with potent antitumor activity.1,2 It displayed an average IC50 of 30 nM over 28 cancer cell lines (IC50 range was 5 nM to 400 nM) .2 Dp44mT retained its antiproliferative activity in both etoposide-resistant MCF-7/VP clones (MCF-7 breast cancer cells) and vinblastine-resistant KB-VB1 clones (KB3-1 epidermoid carcinoma cells) with an IC50 = 12 nM for both lines.2 The potency of Dp44mT has been attributed to the high redox activity of the Dp44mT-Fe complex leading to cytotoxic ROS generation. The antitumor activity of Dp44mT may also be mediated by a redox active copper complex that causes cellular glutathione depletion and lysosomal damage.3,4 It also inhibited T-cell activation and prevented CD25 up-regulation via a copper-dependent mechanism.5

Conjugation

Unconjugated

Buffer

Orange solid

Storage Conditions

-20°C

Alternative Products

Catalog	Name
B6021-50	Dp44mT
A15907-200	Dp44mT 200mg
A15907-25	Dp44mT 25mg
A15907-50	Dp44mT 50mg
A15907-5	Dp44mT 5mg
A15907-100	Dp44mT 100mg
A15907-10	Dp44mT 10mg

Dp44mT

Alternative Products

Popular Products