Deferasirox

• Background:

  Clinically useful iron chelator used in long term care of ß-thalassemia and other heavily transfused hematological patients.1,2 It has been shown to potent inhibitor of JumonjiC Domain-Containing Histone Demethylases (IC50’s = KDM4A (JMJD2A) 4.76 µM, KDM5A (JARID1A) 5.00 µM, KDM6B (JMJD3) 3.95 µM) .3 Deferasirox has also been investigated as a potential anticancer agent.4-6

• Conjugation:

  Unconjugated

• Buffer:

  Off-white to white solid

• Storage Conditions:

  -20°C