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GSK2656157

CAT: 0498-bs-83049C-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0498-bs-83049C-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Potent (IC50 = 0.9 nM) and selective (over 300 kinases) inhibitor of protein kinase RNA-like endoplasmic reticulum kinase (PERK) .1,2 Inhibited growth of multiple human tumor xenografts in mice. GSK2656157 has also been found to potently inhibit RIPK1 (IC50 = 69 nM) and TNF-mediated RIPK1 kinase-dependent cell death in mouse embryonic fibroblasts.3 It prevented the loss of dendritic spines and rescued memory deficits after traumatic brain injury.4 GSK2656157 also enhanced glucose-stimulated insulin secretion in a mouse model of type 2 diabetes mellitus.5
Conjugation
Unconjugated
Buffer
White solid
Storage Conditions
-20°C

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CatalogName
HY-13820-01GSK2656157

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