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NH125

CAT: 0498-bs-83045C-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0498-bs-83045C-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
NH125 was originally discovered as an antibacterial agent active against various Gram-positive and -negative bacteria via inhibition of histidine protein kinase.1 It was also found to be a potent inhibitor of eukaryotic elongation factor 2 (eEF-2) kinase (IC50 = 60 nM) with efficacy against a broad spectrum of human cancer cell lines.2 Other studies have linked the anticancer effects of NH125 to induction of eEF2 phosphorylation.3,4 NH125 has also been shown to engage the EIF2a-ATF4-CHOP axis resulting in induction of DR5 expression.5 Treatment of glioma stem cells with NH125 resulted in a sustained decrease in tumor volume via activation of integrated stress response (ISR) and GADD45 pathways.5
Conjugation
Unconjugated
Buffer
Off-white solid
Storage Conditions
-20°C

Alternative Products

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A8814-2NH125
A14307-5NH125 5mg
A14307-1NH125 1mg
A14307-10NH125 10mg
A14307-2NH125 2mg
A14307-50NH125 50mg
A14307-100NH125 100mg
A14307-25NH125 25mg
A14307-10mM-DNH125 10mM * 1mL in DMSO

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