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WP1066

CAT: 0498-bs-83041C-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0498-bs-83041C-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
WP1066 (857064-38-1) is an inhibitor of the JAK2/STAT3 pathway as well as STAT5 and AKT.1,2,3 It downregulated Bcl-XL, Mcl-1, and c-myc while activating Bax and inducing apoptosis.1 Active against human malignant glioma U87-MG (IC50 = 5.6µM) and U373-MG (IC50 = 3.7µM) cells. Enhances T-cell cytotoxicity via inhibition of regulatory T-cells.4,5 WP1066 abrogated PD-L1 expression in lymphoma cell lines.6
Conjugation
Unconjugated
Buffer
White solid
Storage Conditions
-20°C

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CatalogName
A4140-10WP1066
A11795-100WP1066 100mg

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