NU7441

• Background:

  NU7441 is a potent (IC50 = 13 nM) and selective ATP-competitive inhibitor of DNA-dependent protein kinase (DNA-PK) .1,2 It increased the toxicity of ionizing radiation and etoposide on SW620 human colon cancer lines via impeding of DNA double-strand break repair.3 NU7441 also increased the radio/chemosensitivity of various other cancer cell lines.3-6

• Conjugation:

  Unconjugated

• Buffer:

  Off-white to beige solid

• Storage Conditions:

  -20°C