Acalabrutinib

CAT: 0498-bs-83027C-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0498-bs-83027C-01Size:5 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Background

Acalabrutinib (1420477-60-6) is a highly selective, potent (IC50 = 3nM), and irreversible inhibitor of Bruton’s tyrosine kinase (BTK) .1 Improved target selectivity (especially against TEC family kinases and EGFR) decreased the number of serious side effects observed with Ibrutinib.2 Acalabrutinib significantly inhibits BCR signaling, inhibits tumor proliferation, and reduces tumor burden.3 Clinically useful agent for treating B-cell cancers. BTK has also been shown to have a role in modulating the innate immune system, especially in dendritic cells and macrophages, suggesting a possible role in immunotherapy.4

Conjugation

Unconjugated

Buffer

Yellow solid

Storage Conditions

-20°C

Alternative Products

Catalog	Name
FA138815-01	Acalabrutinib
HY-17600R-01	Acalabrutinib (Standard)
AR-A05277-01	Acalabrutinib-d4
BUP12133-01	Acalabrutinib enantiomer
AR-A08073-01	R-Acalabrutinib
HY-W757743	Acalabrutinib-d3
JH919586	Acalabrutinib Intermediate

Acalabrutinib

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