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Alectinib

CAT: 0498-bs-83023C-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0498-bs-83023C-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Alectinib is a potent (IC50 = 1.9 nM) and highly selective ALK inhibitor.1 It blocked phosphorylation of both native ALK and the L1196M, C1156Y, and F1174L mutants. Alectinib has also been shown to inhibit RET kinase (IC50 = 4.8 nM), the RET gatekeeper mutations V804L and V804M, and inhibited the growth of RET fusion positive cells.2 Alectinib is clinically useful in the treatment of ALK-positive Non-Small Cell Lung Cancer. It effectively suppressed cell proliferation and induced apoptosis in a mouse neuroblastoma xenograft.3
Conjugation
Unconjugated
Buffer
White solid
Storage Conditions
-20°C

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C08838-1gAlectinib
A4649-25Alectinib Hydrochloride
TMID-0073-01Alectinib-d8
ENZ-CHM213-0200Alectinib . hydrochloride
HY-13011A-01Alectinib (Hydrochloride)
HY-13011S1Alectinib-d6

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