Duvelisib

CAT: 0498-bs-83019C-01Size: 5 mgDry Ice: NoHazardous: No

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CAT#:0498-bs-83019C-01Size:5 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Background

Duvelisib (1201438-56-3) is a potent and selective (IC50’s: PI3Kα = 1602nM, PI3Kβ = 85nM, PI3Kδ= 2.5nM, PI3Kγ = 27nM) dual PI3Kδ/γ inhibitor.1 It inhibits B and T cell proliferation, blocks neutrophil migration, and inhibits basophil activation. Duvelisib antagonizes B-cell receptor crosslinking activated pro-survival signals in primary chronic lymphocytic leukemia cells.2 Duvelisib also shows preclinical/clinical activity against other hematologic malignancies such as Non-Hodgkins lymphoma, T-cell lymphoma, ande others.3,4 Useful clinical agent for the treatment of various blood cancers. Low-dose treatment of T-cell-inflamed tumor models of head and neck cancers with Duvelisib enhanced responses to PD-L1 blockade via suppression of myeloid-derived suppressor cells.5 Higher doses reversed the effect due to suppression of tumor-infiltrating T lymphocytes

Conjugation

Unconjugated

Buffer

White solid

Storage Conditions

-20°C

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Catalog	Name
BUP14419-01	Duvelisib
TRC-D739402-10MG	Duvelisib-d5
TRC-D739405-50MG	Duvelisib-Glu
MBS5813345	Duvelisib hydrate
AR-D07910-01	Ent-Duvelisib
abx182436-01	Duvelisib int
HY-17044R-01	Duvelisib (Standard)
MBS3614832-01	Duvelisib(R enantiomer)
RM-D850002-01	N-Nitroso-Duvelisib
ENZ-CHM223-0050	Duvelisib (free base)

Duvelisib

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