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IPA-3

CAT: 0498-bs-83011C-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0498-bs-83011C-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
IPA-3 is a selective allosteric inhibitor of Group 1 p21-activated kinase (PAK1 IC50 = 2.5 µM) 1 via covalent binding to the PAK1 regulatory domain preventing binding to the upstream activator Cdc422. IPA-3 has been shown to induce cell death in human leukemic cell lines3, significantly inhibit TGFβ1-induced prostate cell epithelial to mesenchymal transition4 and inhibits the growth of liver cancer cells5.
Conjugation
Unconjugated
Buffer
Yellow solid
Storage Conditions
-20°C

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CatalogName
M18540-01IPA-3
452436-01IPA 3

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