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GSK583

CAT: 0498-bs-83008C-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0498-bs-83008C-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
GSK583 is a highly selective and potent inhibitor of RIP2 kinase, IC50 = 5 nM human and IC50 = 2 nM rat.1 It also potently Inhibits isolated RPI3 kinase (IC50 = 5 nM) but is inactive against RIP3 in cellular assays due to a very low KM, ATP. GSK583 blocks NOD2 signaling by interfering with XIAP-RIP2 binding resulting in decreased cytokine and chemokine production.1,2
Conjugation
Unconjugated
Buffer
Pale yellow solid
Storage Conditions
-20°C

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