AE 51310

CAT: 0498-bs-82970C-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0498-bs-82970C-01Size:5 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
AE 51310 is a potent antagonist of the GPCR OPN4/melanopsin (Ki = 0.096 nM human OPN4) .1 OPN4 regulates circadian rhythms, pupil functions, melatonin expression, cognition, and sleep. OPN4 has been found to bind G11 in lung cancer cells modulating PKC activation leading to activation of BRAF/MEK/ERK signaling pathways. AE 51310 decreased the growth and proliferation of both LG17 and LG55 lung cancer tumors in mouse xenograft models.
Conjugation
Unconjugated
Buffer
White solid
Storage Conditions
-20°C

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