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Nitisinone

CAT: 0498-bs-82966C-01Size: 50 mgDry Ice: NoHazardous: No
CAT#:0498-bs-82966C-01Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Inhibitor of 4-Hydroxyphenylpyruvate dioxygenase (HPPD; IC50 = 40 nM1 and 173 nM2) and is in clinical use for the treatment of hereditary tyrosinemia type 13. CD13+ cancer stem cells (CSCs) are dependent on aerobic metabolism of tyrosine - Nitisinone inhibition of tyrosine metabolism results in lowered availability of acetyl-CoA and fumarate for use in the citric acid cycle causing these CSCs to enter cell cycle, decreasing self-renewal, and making them more susceptible to chemotherapy.4 Nitisinone is a potential treatment option for cancers that rely on tyrosine metabolism.
Conjugation
Unconjugated
Buffer
Beige solid
Storage Conditions
-20°C

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